|
KMID : 0357119920140010009
|
|
Korean Journal of Immunology
1992 Volume.14 No. 1 p.9 ~ p.14
|
|
|
Characteristics of Interleukin 40induced CD23-positive Human B cells
|
|
|
|
|
Abstract
|
|
|
CD23, the low affinity IgE receptor(EcωRII), had been thought to be related to B cell growth and IgE regulation. The present study was undertaken to investigate the characteristics ofd CD23-positive(CD23+) cells induced by IL-4 from human
tonsillar
lymphocytes culture. IL-4 induced CD23 expression on 50-60% of B cells after 48hours of culture. Fifteen to 20% of CD23+ cells were large in their sizes. CD23 was expresed continuously without further treatment of IL-4. When cells were recultured
after
three days CD23+ cells showed higher viability and significantly higher proliferative responses to several mitogens as compared to CD23 negative(CD23-) cells. Seventy to 80% of CD23+ cells coexpressed sIgM/SigD, and 40% expressed sIgsa, sIgE or
sIgG.
These results imply that IL-4 seems to act in the early stage of cell culture and CD23 antigen might play an important role in activating and keeping long life span of B cells.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
 
|